Nanjing Vtrying PharmTech

Iguratimod is a disease-modifying antirheumatic drug (DMARD) primarily used for the treatment of rheumatoid arthritis (RA). Here's a detailed breakdown:

1. Classification:

   • Synthetic small-molecule DMARD.

   • Classified as a targeted synthetic DMARD (tsDMARD).

2. Mechanism of Action (Unique & Multi-targeted):

   • Inhibition of Cytokine Production: Significantly suppresses the production of pro-inflammatory cytokines crucial in RA pathogenesis, including:

     • TNF-α (Tumor Necrosis Factor-alpha)

     • IL-1β (Interleukin-1 beta)

     • IL-6 (Interleukin-6)

     • IL-8 (Interleukin-8)

     • IL-17 (Interleukin-17)