Nanjing Vtrying PharmTech

Posaconazole is a triazole antifungal drug derived from itraconazole and first launched in the United States in 2006. The information related to its raw materials is as follows:

Chemical structure

The molecular formula is C ∝₇ H ₄₂ F ₂ N ₈ O ₄, and the CAS number is 171228-49-2. The chemical structure includes complex functional groups such as triazole ring and oxazole ring.  ‌

Physical property

The appearance is a white solid with a melting point of 170-172 ° C and a density of 1.36 g/cm ³. The solubility is significantly affected by pH.  ‌

Indication

Mainly used for the prevention and treatment of invasive Aspergillus and Candida infections, suitable for patients with immune dysfunction (such as hematopoietic stem cell transplantation and chemotherapy-induced neutropenia).  ‌

Dosage Form and Usage

Including oral suspension (40mg/ml), sustained-release tablets (100mg), and intravenous injections (launched in 2021), the dosage needs to be adjusted according to renal function